Work

Pathogenic mechanisms in HBV- and HCV-associated hepatocellular carcinoma

Year: 2013

Type: review

Abstract: Hepatocellular carcinoma (HCC) is mainly associated with chronic hepatitis B virus (HBV) and/or hepatitis C virus (HCV) infections. This Review outlines pathogenic mechanisms that seem to be common to both HBV and HCV, in the hope that this might suggest innovative approaches for the prevention and treatment of HCC. Hepatocellular carcinoma (HCC) is a highly lethal cancer, with increasing worldwide incidence, that is mainly associated with chronic hepatitis B virus (HBV) and/or hepatitis C virus (HCV) infections. There are few effective treatments partly because the cell- and molecular-based mechanisms that contribute to the pathogenesis of this tumour type are poorly understood. This Review outlines pathogenic mechanisms that seem to be common to both viruses and which suggest innovative approaches to the prevention and treatment of HCC.

Source: Nature reviews. Cancer

DOI: 10.1038/nrc3449

Authors: Alla Arzumanyan, Helena M. G. P. V. Reis, Mark A. Feitelson

Institutions: Sbarro Health Research Organization, Temple University

Language: English

Topic: Hepatitis B Virus Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Cancer Institute, National Institute of Allergy and Infectious Diseases