Work

NALP3: a key player in caspase-1 activation

Year: 2006

Type: article

Abstract: The NLR (NACHT-LRR) family of proteins have been implicated in the regulation of immune responses and cell death pathways. Some NLR family members can form multiprotein complexes, called inflammasomes, involved in the activation of pro-inflammatory caspases. Mutations in the NALP3/CIAS1/cryopyrin gene, a member of the NLR family, are linked to three auto-inflammatory disorders: Muckle-Wells syndrome, familial cold auto-inflammatory syndrome and neonatal-onset multisystem inflammatory disease. NALP3 along with the adaptor molecule ASC activates caspase-1 in response to a wide variety of stimuli. Here we review recent findings on the biology of NALP3 suggesting that it has functions beyond that of pathogen recognition.

Source: Journal of Endotoxin Research

DOI: 10.1177/09680519060120040701

Authors: Fayyaz S. Sutterwala, Yasunori Ogura, Dario S. Zamboni, Craig R. Roy, Richard A. Flavell

Institutions: Yale University, Howard Hughes Medical Institute

Language: English

Topic: Inflammasome and immune disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Howard Hughes Medical Institute, National Institutes of Health, National Institute of Allergy and Infectious Diseases