Work

GWAS meta analysis identifies TSNARE1 as a novel Schizophrenia / Bipolar susceptibility locus

Year: 2013

Type: article

Abstract: We carried out a GWAS meta-analysis of combined mixed-ancestry schizophrenia, schizoaffective, and bipolar cohorts that resulted in the identification of six genome-wide significant loci, including one novel locus at chr8q24.3, encompassing TSNARE1 (P = 1.28 × 10(-9)). The analysis included a total of 13,394 cases and 34,676 controls. While the function of TSNARE1 remains unknown, bioinformatic predictions based on phylogenetic ancestry indicate it may have a vertebrate-specific function in intracellular protein transport and synaptic vesicle exocytosis.

Source: Scientific Reports

DOI: 10.1038/srep03075

Authors: Patrick Sleiman, Dai Wang, Joseph Glessner, Dexter Hadley, Raquel E. Gur, Nadine Cohen, Qingqin Li, Hakon Hakonarson, the Janssen-CHOP Neuropsychiatric Genomics Working Group, Patrick Sleiman, Joseph Glessner, Dexter Hadley, Charlly Kao, Zhi-liang Wu, Cecilia Kim, Kelly Thomas, Hakon Hakonarson, Dai Wang, Reyna Favis, Dong-Jing Fu, Hedy Chung, Adam Savitz, Srihari Gopal, Nadine Cohen, Qingqin Li

Institutions: Children's Hospital of Philadelphia, University of Pennsylvania, Janssen Research & Development (United States), Janssen Scientific Affairs (United States)

Language: English

Topic: Schizophrenia research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,690

Funders: Children's Hospital of Philadelphia, University of Pennsylvania, Cotswold Foundation, National Institute of Mental Health

Awards: 1/3-Networks from Multidimensional Data for Schizophrenia and Related Disorders, 3/3-Networks from Multidimensional Data for Schizophrenia and Related Disorders

OpenAlex ID: W1982756878

FWCI: 2.126

Cites: 17

Cited by: 48

Related to: 10