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Circulating Monocytes Are Not a Major Reservoir of HIV-1 in Elite Suppressors

Year: 2011

Type: article

Abstract: Circulating HIV-1-infected monocytes have been identified in patients on highly active antiretroviral therapy and may represent an important barrier to viral eradication. The nature of these cells in HIV-1-infected patients who maintain undetectable viral loads and preserved CD4(+) T cell counts without antiretroviral therapy (known as elite controllers or elite suppressors [ES]) is unknown. We describe here infrequent recovery of proviral HIV-1 DNA from circulating monocytes relative to CD4(+) T cells in ES, despite permissiveness of these cells to HIV-1 viral entry ex vivo. Thus, monocytes do not appear to be a major reservoir of HIV-1 in ES.

Source: Journal of Virology

DOI: 10.1128/jvi.05409-11

Authors: Adam M. Spivak, Maria Salgado, S. Alireza Rabi, Karen A. O'Connell, Joel N. Blankson

Institutions: Johns Hopkins University, Johns Hopkins Medicine

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Allergy and Infectious Diseases