Work

Design Strategies for Aptamer-Based Biosensors

Year: 2010

Type: review

Abstract: Aptamers have been widely used as recognition elements for biosensor construction, especially in the detection of proteins or small molecule targets, and regarded as promising alternatives for antibodies in bioassay areas. In this review, we present an overview of reported design strategies for the fabrication of biosensors and classify them into four basic modes: target-induced structure switching mode, sandwich or sandwich-like mode, target-induced dissociation/displacement mode and competitive replacement mode. In view of the unprecedented advantages brought about by aptamers and smart design strategies, aptamer-based biosensors are expected to be one of the most promising devices in bioassay related applications.

Source: Sensors

DOI: 10.3390/s100504541

Authors: Kun Han, Zhiqiang Liang, Nandi Zhou

Institutions: Chinese Academy of Sciences, Suzhou Institute of Biomedical Engineering and Technology, Nanjing University, Shanghai University, Jiangnan University

Language: English

Topic: Advanced biosensing and bioanalysis techniques

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $3,137

Funders: National Natural Science Foundation of China, Jiangnan University