Work

Synthesis of Bicyclic Guanidines via Cascade Hydroamination/Michael Additions of Mono- N -acryloylpropargylguanidines

Year: 2014

Type: article

Abstract: A cascade silver(I)-catalyzed hydroamination/Michael addition sequence has been developed to deliver highly substituted bicyclic guanidines. This transformation gives rise to geometrically and constitutionally stable ene-guanidines and generates a remote stereocenter with moderate to high diastereoselectivity.

Source: Organic Letters

DOI: 10.1021/ol502691w

Authors: Ki-Hyeok Kwon, Catherine M. Serrano, Michael Koch, Louis R. Barrows, Ryan E. Looper

Institution: University of Utah

Language: English

Topic: Catalytic Alkyne Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500