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Correction: Chemerin Is an Antimicrobial Agent in Human Epidermis

Year: 2013
Type: erratum
Abstract: Chemerin, a chemoattractant ligand for chemokine-like receptor 1 (CMKLR1) is predicted to share similar tertiary structure with antibacterial cathelicidins.Recombinant chemerin has antimicrobial activity.Here we show that endogenous chemerin is abundant in human epidermis, and that inhibition of bacteria growth by exudates from organ cultures of primary human skin keratinocytes is largely chemerin-dependent.Using a panel of overlapping chemerin-derived synthetic peptides, we demonstrate that the antibacterial activity of chemerin is primarily mediated by Val 66 -Pro 85 , which causes direct bacterial lysis.Therefore, chemerin is an antimicrobial agent in human skin.
Source: PLoS ONE
DOI: 10.1371/annotation/4dfd522c-f0fd-40db-aadc-44cbef367a40
Authors: Magdalena Banas, Katarzyna Zabieglo, Gopinath Kasetty, Monika Kapinska-Mrowiecka, Julia Borowczyk, Justyna Drukala, Krzysztof Murzyn, Brian A. Zabel, Eugene C. Butcher, Jens M. Schroeder, Artur Schmidtchen, Joanna Cichy
Institutions: Jagiellonian University, Lund University, VA Palo Alto Health Care System, Palo Alto Veterans Institute for Research, Stanford Medicine, Stanford University, University Hospital Schleswig-Holstein, Charité – Universitätsmedizin Berlin
Language: English
Subfield: Microbiology
Open Access status: gold
Estimated APC paid: $2,382
OpenAlex ID: W1983199960
Cites: 32
Cited by: 22
Related to: 10