Work

The N-end rule: functions, mysteries, uses.

Year: 1996

Type: article

Abstract: The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue. Similar but distinct versions of the N-end rule operate in all organisms examined, from mammals to fungi and bacteria. In eukaryotes, the N-end rule pathway is a part of the ubiquitin system. I discuss the mechanisms and functions of this pathway, and consider its applications.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.93.22.12142

Author: A Varshavsky

Institution: California Institute of Technology

Language: English

Topic: Ubiquitin and proteasome pathways

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W1983345237

FWCI: 7.809

Cites: 75

Cited by: 853

Related to: 10