Work

Sonophoric nanoprobe aided pH measurement in vivo using photoacoustic spectroscopy

Year: 2013

Type: article

Abstract: Presented here is a novel method of in vivo pH sensing utilizing a hybrid optical imaging technique, photoacoustic imaging (PAI), and pH sensitive polymeric nanoprobes. Nanoprobes with hydrophobic core containing a pH sensitive dye were synthesized and used to measure the pH level ex vivo first and then in vivo by performing experiments on a rat joint model, with an achieved precision of less than 0.1 pH units. The ability of the hydrophobic functional groups in the polyacrylamide matrix to shield the molecular dye from being affected by the proteins in the plasma, and prevent the dye from leaching out, is also demonstrated.

Source: The Analyst

DOI: 10.1039/c3an00093a

Authors: Aniruddha Ray, Hyung Ki Yoon, Yong Eun Koo Lee, Raoul Kopelman, Xueding Wang

Institution: University of Michigan

Language: English

Topic: Photoacoustic and Ultrasonic Imaging

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Awards: G104201763, G2941753140, G6279485043