Work

Cyclopentadienyltricarbonylrheniumbenzazepines: synthesis and binding affinity

Year: 2000

Type: article

Abstract: Analogues of the benzazepine dopamine D1 receptor antagonist SCH-23390 incorporating the cyclo-pentadienyltricarbonyl-rhenium (CPTR) moiety were synthesized and evaluated pharmacologically. The CPTR derivatives retained affinity (0.3-2.9 nM) and D1 selectivity of the parent compound, supporting their use as neuropharmacological surrogates for 99mTc-labeled SPECT radiopharmaceuticals.

Source: Bioorganic & Medicinal Chemistry Letters

DOI: 10.1016/s0960-894x(00)00185-2

Authors: Gilles Tamagnan, Ronald M Baldwin, Nora S Kula, Ross J Baldessarini, Robert B Innis

Institutions: Yale University, VA Connecticut Healthcare System, Harvard University, McLean Hospital, Massachusetts General Hospital

Language: English

Topic: Radiopharmaceutical Chemistry and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

Open Access status: hybrid

Estimated APC paid: $3,880

Funders: National Institutes of Health, National Institute of Mental Health