Work

The carbonate radical and related oxidants derived from bicarbonate buffer

Year: 2007

Type: review

Abstract: The unequivocal demonstration that the carbonate radical (CO(3) (.-)) is produced from the reaction between the ubiquitous carbon dioxide and peroxynitrite, renewed the interest in the pathogenic roles of oxidants derived from the main physiological buffer, the bicarbonate-carbon dioxide pair. Here, we review the biochemical properties of both the carbonate radical and peroxymonocarbonate (HCO(4) (-)), and discuss the evidence of their formation under physiological conditions. Overall, the review emphasizes the recognition of the biological relevance of oxidants derived from the main physiological buffer as a crucial step into the understanding and control of numerous pathological states.

Source: IUBMB Life

DOI: 10.1080/15216540701230511

Authors: Danilo B. Medinas, Giselle Cerchiaro, Daniel F. Trindade, Ohara Augusto

Institution: Universidade de São Paulo

Language: English

Topic: Redox biology and oxidative stress

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: Fundação de Amparo à Pesquisa do Estado de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico

OpenAlex ID: W1983606357