Subjective cognitive concerns, episodic memory, and the APOE ε4 allele
Year: 2014
Type: article
Abstract: BACKGROUND: Subjective cognitive concerns may represent a simple method to assess likelihood of memory decline among apolipoprotein E (APOE) ε4 carriers. METHODS: We examined the relationship of self-reported subjective cognitive concerns, using seven specific cognitive concerns, with memory and memory decline over 6 years among APOE ε4 carriers and non-carriers from the Nurses' Health Study. RESULTS: In both groups, increasing subjective cognitive concern score predicted worse baseline memory and faster rates of subsequent memory decline, after adjustment for age, education and depression. The relation with baseline memory appeared statistically stronger in APOE ε4 carriers (P-interaction = 0.03). For memory decline, mean differences in slopes of episodic memory (95% CI) for 4 to 7 versus no concern = -0.05 (-0.10, 0.01) standard units in APOE ε4 carriers, and -0.04 (-0.08, -0.01) standard units in non-carriers. CONCLUSIONS: APOE ε4 carriers with self-assessed cognitive concerns appear to have worse memory, and possibly accelerated memory decline.
Source: Alzheimer s & Dementia
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1702860912, Subjective cognitive complaints: An early indicator of AD, Dietary Fat Composition, Plasma Lipids, and Cognitive Decline, Dietary and Hormonal Determinants of Cancer in Women, Mentoring Imaging Research in Early AD, Functional Impairment from Stroke: an Exploratory Study of Disparities, Alzheimer's Disease Cooperative Study (ADCS), G5213773064, Evolution of memory related fMRI activation over the course of MCI and AD, Optimizing measures of subjective and objective decline in preclinical AD, Characterizing the Evolution of Amyloid Deposition in Normal Elderly, Massachusetts Alzheimer's Disease Research Center, Alzheimer's Disease Cooperative Study, G885693336, G9000164495, Impact of Amyloid and Tau on the Aging Brain: The Harvard Aging Brain Study, Massachusetts Alzheimer's Disease Research Center (MADRC)
OpenAlex ID: W1983685388