Year: 1962
Type: article
Abstract: patients who responded better to betamethasone than to hydrocortisone or triamcinolone did so because of the development of partial resistance to those steroids after prolonged use: this phenomenon has been observed before (Vickers and Tighe, 1960).In patients with chronic dermatoses, especially those with atopic eczema, such variations of local steroid therapy may be very helpful in maintaining reasonable control of an other- wise disabling condition.No adverse reactions have been seen to the preparations tested.SUMMARY Double-blind paired comparison trials of topical applications of a new steroid, betamethasone, and hydrocortisone are described, together with results of more extensive clinical use.In this investigation betamethasone phosphate 0.1% and hydrocortisone 1 % were shown to be of equal potency.I thank Drs. I. B. Sneddon and R. E. Church for permitting me to treat their patients, and Glaxo Laboratories for supplies of the various local steroid applications; 1% hydrocortisone (" efcortelan "), 0.1 % betamethasone phosphate (" betnesol "), and 0.1% betamethasone alcohol (" betnelan ").
Source: BMJ
Authors: B. A. Sayed, S. P. Amin
Institution: Salford Royal Hospital
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W1983723285