Work

Constitutively Signaling G-Protein-Coupled Receptors and Human Disease

Year: 1998

Type: review

Abstract: Dysregulation of G-protein-coupled receptor (GPCR) function has been shown to be associated with a growing number of human diseases. In some diseases, mutation of an endogenous GPCR causes the receptor to lose the ability to bind agonist or signal (;loss of function' mutation), whereas another mutation causes the receptor to be in an active state in the absence of agonist (;gain of function' mutation), leading to ;constitutive signaling activity'. A number of constitutively active GPCRs are tumorigenic in vitro and in animal models, and cause syndromes of hyperfunction and/or tumors in humans. The recent characterization of a constitutively active GPCR in the genome of a disease-associated, human herpesvirus provides a potential novel mechanism for viral tumorigenesis.

Source: Trends in Endocrinology and Metabolism

DOI: 10.1016/s1043-2760(98)00007-1

Authors: Leandros Arvanitakis, Elizabeth Geras-Raaka, Marvin C Gershengorn

Institutions: Pasteur Hellenic Institute, Cornell University

Language: English

Topic: Receptor Mechanisms and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $7,030