Year: 2001
Type: review
Abstract: Beginning with its discovery in 1986 and continuing through the present, the transcription factor NF-kB has attracted widespread interest based on its unusual regulation, the variety of stimuli that activate it, the diverse genes and biological responses that it controls, the striking evolutionary conservation of structure and function among family members, and its apparent involvement in a variety of human diseases (Table 1). Importantly, and consistent with the last point, NF-kB has been shown to be the target of several anti-inflammatory and anticancer drugs.
DOI: 10.1172/jci11891
Author: Albert S. Baldwin
Language: English
Topic: NF-κB Signaling Pathways
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W1983805610