Leishmania specific CD4 T cells release IFN-γ that limits parasite replication in patients with visceral leishmaniasis
Year: 2014
Type: article
Abstract: Background: An immunological feature of VL patients is the inability of PBMC to respond to leishmanial antigen. But unexpectedly, it was recently found that Leishmania specific IFN-γ, can readily be detected when a whole blood stimulation assay is used. We explored the conditions that permit whole blood cells to respond to antigen stimulation, and clarify the biological role of the IFN-γ.
Authors: N. Singh, R. Kumar, S. Gautam, O.P. Singh, K. Gidwani, M. Rai, S. Sundar, S. Nylén, D. Sacks
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,900
OpenAlex ID: W1983927356