Work

Dendritic cell ontogeny: A human dendritic cell lineage of myeloid origin

Year: 1997

Type: article

Abstract: Dendritic cells (DC) have been thought to represent a family of closely related cells with similar functions and developmental pathways. The best-characterized precursors are the epidermal Langerhans cells, which migrate to lymphoid organs and become activated DC in response to inflammatory stimuli. Here, we demonstrate that a large subset of DC in the T cell-dependent areas of human lymphoid organs are nonactivated cells and belong to a separate lineage that can be identified by high levels of the interleukin 3 receptor alpha chain (IL-3Ralphahi). The CD34+IL-3Ralphahi DC progenitors are of myeloid origin and are distinct from those that give rise to Langerhans cells in vitro. The IL-3Ralphahi DC furthermore appear to migrate to lymphoid organs independently of inflammatory stimuli or foreign antigens. Thus, DC are heterogeneous with regard to function and ontogeny.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.94.23.12551

Authors: Johanna Olweus, Andrew BitMansour, Roger Warnke, Peter A. Thompson, Jose Carballido, Louis J. Picker, Fridtjof Lund-Johansen

Institutions: The University of Texas Southwestern Medical Center, Stanford University, Merck & Co., Inc., Rahway, NJ, USA (United States)

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W1984015030

FWCI: 9.132

Cites: 44

Cited by: 477

Related to: 9