Cerebral Ventricular Injections of Pentobarbital, Glucose, and Sodium Chloride into Sheep and Calves, and Feeding,
Year: 1972
Type: article
Abstract: Experiments determined if areas of ovine and bovine brain can be inactivated, thereby releasing the inhibition on eating in a satiated animal.Pentobarbital sodium, a neural depressant, was injected into a lateral cerebral ventricle to test this possibility.Glucose and NaC1 solutions of osmolality (2,650 milliosmoles/kg H20) similar to the pentobarbital were also tested.Eating began within 7 rain after injection of 29.4 mg of pentobarbital and continued intermittently for averages of 27 and 32 min in sheep and calves.Average food intake of sheep (18 observabions) for the half-hour following pentobarbital injection versus the same time on noninjection days was 344.5 ± SE. 44.8 g versus 42.8 ± 6.6 g (P<.001).Growing calves also showed an increase (P<.001) in food intake for 30 min following pent,)barbital injection (9.37 ~ .73g/kg versus 1.23 ----.18g/kg).A 32% glucose solution (.45 ml) injected into the lateral ventricle of sheep resulted in variable responses but generally did not increase food intake.The same amount of glucose injected into a lateral ventricle of calves, the injection made over 5.5 rain, increased food intake above noninjection periods (P<.05).In sheep, ventricular injections of sodium chloride solution induced drinking within 7 rain but did not induce eating.We propose
Source: Journal of Dairy Science
Authors: A.D. Peterson, C.A. Baile, B.R. Baumgardt
Institutions: Pennsylvania State University, Harvard University
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W1984058095