Work

Mosaic trisomy 21 and trisomy 14 as acquired cytogenetic abnormalities without GATA1 mutation in a pediatric non-down syndrome acute megakaryoblastic leukemia

Year: 2011

Type: article

Abstract: One case of acute megakaryoblastic leukemia (AMKL) with trisomy 21, trisomy 14 and unmutated GATA1 gene in a phenotypically normal girl was reported. The patient experienced transient myelodysplasia before the onset of AMKL. The bone marrow blasts manifested typical morphology of megakaryoblast both by the May-Giemsa staining and under the electronic microscopy. Leukemic cells were positive for CD13, CD33, CD117, CD56, CD38, CD41 and CD61 in flow cytometry analysis. Cytogenetic study showed karyotype of 48, XX, +14, +21 in 40% metaphases. Known mutations of GATA1 gene in Down syndrome or acquired trisomy 21 were not detected in this case.

Source: Chinese Journal of Cancer Research

DOI: 10.1007/s11670-011-0239-4

Authors: Yi Xiao, Jia Wei, Jin-huan Xu, Jian-feng Zhou, Yi-cheng Zhang

Institutions: Tongji Hospital, Huazhong University of Science and Technology

Language: English

Topic: Acute Myeloid Leukemia Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W1984103357