Year: 2000
Type: conference-abstract
Abstract: Background: Peak oxygen consumption (VOa) is a powerful predictor of outcome in patients with chronic heart failure.This is not a test that is readily clinically available.We therefore sought to establish a method of assessing peak VO:! from non-invasively acquired data.Methods: We analysed the results from incremental treadmill exercise tests in 60 patients (aged 59.0 (SD 12.4) years) with chronic heart failure or left ventricular dysfunction (left ventricular ejection fraction (29.6 (15.2)%) and 52 control subjects (aged 36.7 (12.3)).Metabolic gas exchange during exercise was measured with a respiratory mass spectrometer.Heart rate and blood pressure were measured.Resuitat Peak VOz was lower in patients than controls (19.9 (7.7) ml/kg/mm v 38.3 (9.0); P < 0.001).Exercise time (r = 0.84, P < O.OOl), heart rate at peak exercise (r = 0.63, p < 0.0001).change in heart rate (r = 0.72; p < O.OOOl), rate pressure product at peak exercise (r = 0.64, p < 0.0001) and change in systolic blood pressure.(r = 0.31, p = 0.002) all correlated with peak VO2.In a stepwise regression model, exercise time was the most powerful predictor of peak VO2 (r2 = 0.79).The only additional independent variable was change in heart rate from rest to peak exercise, which increased r2 to 0.80.In a survival analysis, measured peak VOa and the peak VO2 estimated from exercise time and change in heart rate had similar predictive power. Conclusions:In this preliminary study, peak VO:, can be estimated from non-invasively acquired parameters.Estimated peak VO2 and measured peak VO2 have similar predictive power for outcome.Further work is necessary to see if estimated peak VO2 is widely applicable in a clinical setting.
Institutions: University of Padua, San Diego State University
Language: English
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W1984222155