Work

Activation of the hypothalamic-pituitary-adrenal stress axis induces cellular oxidative stress

Year: 2015

Type: review

Abstract: Glucocorticoids released from the adrenal gland in response to stress-induced activation of the hypothalamic-pituitary-adrenal (HPA) axis induce activity in the cellular reduction-oxidation (redox) system. The redox system is a ubiquitous chemical mechanism allowing the transfer of electrons between donor/acceptors and target molecules during oxidative phosphorylation while simultaneously maintaining the overall cellular environment in a reduced state. The objective of this review is to present an overview of the current literature discussing the link between HPA axis-derived glucocorticoids and increased oxidative stress, particularly focussing on the redox changes observed in the hippocampus following glucocorticoid exposure.

Source: Frontiers in Neuroscience

DOI: 10.3389/fnins.2014.00456

Authors: Jereme G. Spiers, Hsiao-Jou Cortina Chen, Conrad Sernia, Nickolas A. Lavidis

Institution: The University of Queensland

Language: English

Topic: Stress Responses and Cortisol

Subfield: Behavioral Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801