Year: 2013
Type: article
Abstract: SNPs in the first intron of FTO (fat mass and obesity associated) are strongly associated with human obesity. While it is not yet formally established that this effect is mediated through the actions of the FTO protein itself, loss of function mutations in FTO or its murine homologue Fto result in severe growth retardation, and mice globally overexpressing FTO are obese. The mechanisms through which FTO influences growth and body composition are unknown. We describe a role for FTO in the coupling of amino acid levels to mammalian target of rapamycin complex 1 signaling. These findings suggest that FTO may influence body composition through playing a role in cellular nutrient sensing.
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
Awards: G1258311730, Functional analysis of the fat mass and obesity-associated gene FTO., G4597773953, Cellular Medicine at the Cambridge Institute for Medical Research., Ion Channels and Diseases of Electrically Excitable Cells., NIHR Senior Investigator Award, Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health, European Obesity Consortium studying the Hypothalamus and its Interaction with Peripheral organs, G6844935297, The physiology and pathophysiology of unfolded protein responses.
OpenAlex ID: W1984774548