Work

The CCN family of proteins: structure–function relationships

Year: 2008

Type: review

Abstract: The CCN proteins are key signalling and regulatory molecules involved in many vital biological functions, including cell proliferation, angiogenesis, tumourigenesis and wound healing. How these proteins influence such a range of functions remains incompletely understood but is probably related to their discrete modular nature and a complex array of intra- and inter-molecular interactions with a variety of regulatory proteins and ligands. Although certain aspects of their biology can be attributed to the four individual modules that constitute the CCN proteins, recent results suggest that some of their biological functions require cooperation between modules. Indeed, the modular structure of CCN proteins provides important insight into their structure-function relationships.

Source: Trends in Biochemical Sciences

DOI: 10.1016/j.tibs.2008.07.006

Authors: Kenneth P. Holbourn, K. Ravi Acharya, Bernard Perbal

Institutions: University of Bath, University of Michigan, L'Oreal (United States)

Language: English

Topic: Connective Tissue Growth Factor Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $7,030

Funder: Wellcome Trust