Work

Notch1-dependent lymphomagenesis is assisted by but does not essentially require pre-TCR signaling

Year: 2006

Type: article

Abstract: Overexpression of intracellular Notch plays an important role in the generation of human acute lymphoblastic T cell leukemia (T-ALL). In mouse models, it was shown that Notch-dependent T-ALL required pre-TCR signaling. Here we show that pre-TCR signaling is required to condition mice for Notch-dependent transformation but that it is not required to sustain malignant growth of T-ALL. In contrast to previous studies, we found that disease development does not require pre-TCR but that it can be accelerated in Rag2(-/-) mice by transient mimicking of pre-TCR signals.

Source: Blood

DOI: 10.1182/blood-2006-01-0143

Authors: Antonio F. Campese, Annette I. Garbe, Fangrong Zhang, Fabio Grassi, Isabella Screpanti, Harald von Boehmer