Work

Ultrabright NIR fluorescent mesoporous silica nanoparticles

Year: 2014

Type: article

Abstract: at 805 nm and the quantum yield of the dye increased by a factor of 5 after encapsulating to 1.5%. The fluorescent brightness of these particles is more than 2000× higher than the fluorescence of one molecule of LS277 in water. When exited in NIR spectral region (>700 nm), these particles are up to 4× brighter than QD800 commercial quantum dots emitting at 800 nm. We demonstrate that the synthesized NIR mesoporous silica nanoparticles easily internalize 4T1luc breast tumor cells, and remain bright for more than 9 weeks whereas the dye is completely bleached by that time.

Source: Journal of Materials Chemistry B

DOI: 10.1039/c4tb00287c

Authors: S. Palantavida, R. Tang, G. P. Sudlow, W. J. Akers, S. Achilefu, I. Sokolov

Institutions: Tufts University, Washington University in St. Louis

Language: English

Topic: Luminescence and Fluorescent Materials

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute