Work

Calibration-free in vivo transverse blood flowmetry based on cross correlation of slow time profiles from photoacoustic microscopy

Year: 2013

Type: article

Abstract: We propose a cross-correlation-based method to measure blood-flow velocity by using photoacoustic microscopy. Unlike in previous autocorrelation-based methods, the measured flow velocity here is independent of particle size. Thus an absolute flow velocity can be obtained without calibration. We first measured the flow velocity ex vivo, using defibrinated bovine blood. Then flow velocities in vessels with different structures in a mouse ear were quantified in vivo. We further measured the flow variation in the same vessel and at a vessel bifurcation. All the experimental results indicate that our method can be used to accurately quantify blood velocity in vivo.

Source: Optics Letters

DOI: 10.1364/ol.38.003882

Authors: Yong Zhou, Jinyang Liang, Konstantin I. Maslov, Lihong V. Wang

Institution: Washington University in St. Louis

Language: English

Topic: Photoacoustic and Ultrasonic Imaging

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: bronze

Funders: National Cancer Institute, National Institute of Biomedical Imaging and Bioengineering, National Center for Chronic Disease Prevention and Health Promotion