Work

Oncometabolites: linking altered metabolism with cancer

Year: 2013

Type: review

Abstract: The discovery of cancer-associated mutations in genes encoding key metabolic enzymes has provided a direct link between altered metabolism and cancer. Advances in mass spectrometry and nuclear magnetic resonance technologies have facilitated high-resolution metabolite profiling of cells and tumors and identified the accumulation of metabolites associated with specific gene defects. Here we review the potential roles of such "oncometabolites" in tumor evolution and as clinical biomarkers for the detection of cancers characterized by metabolic dysregulation.

Source: Journal of Clinical Investigation

DOI: 10.1172/jci67228

Authors: Ming Yang, Tomoyoshi Soga, Patrick J. Pollard

Institutions: University of Oxford, Keio University, Institut pour l'avancée des biosciences

Language: English

Topic: Cancer, Hypoxia, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Cancer Research UK, University of Oxford, FP7 Ideas: European Research Council