Work

Neonatal Sepsis and Neutrophil Insufficiencies

Year: 2010

Type: article

Abstract: Sepsis has continuously been a leading cause of neonatal morbidity and mortality despite current advances in chemotherapy and patient intensive care facilities. Neonates are at high risk for developing bacterial infections due to quantitative and qualitative insufficiencies of innate immunity, particularly granulocyte lineage development and response to infection. Although antibiotics remain the mainstay of treatment, adjuvant therapies enhancing immune function have shown promise in treating sepsis in neonates. This article reviews current strategies for the clinical management of neonatal sepsis and analyzes mechanisms underlying insufficiencies of neutrophil defense in neonates with emphasis on new directions for adjuvant therapy development.

Source: International Reviews of Immunology

DOI: 10.3109/08830181003792803

Authors: John Nicholas Melvan, Gregory J. Bagby, David A. Welsh, Steve Nelson, Ping Zhang

Institution: Louisiana State University Health Sciences Center New Orleans

Language: English

Topic: Neonatal and Maternal Infections

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism