Work

Intercellular interplay between Sirt1 signalling and cell metabolism in immune cell biology

Year: 2015

Type: review

Abstract: Sirtuins are evolutionarily conserved class III histone deacetylases that have been the focus of intense scrutiny and interest since the discovery of Sir2 as a yeast longevity factor. Early reports demonstrated an important role of Sirt1 in aging and metabolism, but its critical regulatory role in the immune system has only been unveiled in recent years. In this review we discuss the latest advances in understanding the regulatory role of Sirt1 in immune responses as well as how Sirt1 translates metabolic cues to immune signals, which would bring new insights into both pathogenesis and potential therapeutic strategies of a variety of immune-related diseases, such as cancer, microbial infection, autoimmune diseases and transplantation.

Source: Immunology

DOI: 10.1111/imm.12473

Authors: Xi Chen, Yun Lu, Zhengguo Zhang, Jian Wang, Hui Yang, Guangwei Liu

Institutions: Shanghai Medical College of Fudan University, Fudan University

Language: English

Topic: Sirtuins and Resveratrol in Medicine

Subfield: Geriatrics and Gerontology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Science Foundation, National Natural Science Foundation of China