Work

The RAR1 Interactor SGT1, an Essential Component of R Gene-Triggered Disease Resistance

Year: 2002

Type: article

Abstract: Plant disease resistance (R) genes trigger innate immune responses upon pathogen attack. RAR1 is an early convergence point in a signaling pathway engaged by multiple R genes. Here, we show that RAR1 interacts with plant orthologs of the yeast protein SGT1, an essential regulator in the cell cycle. Silencing the barley gene Sgt1 reveals its role in R gene-triggered, Rar1-dependent disease resistance. SGT1 associates with SKP1 and CUL1, subunits of the SCF (Skp1-Cullin-F-box) ubiquitin ligase complex. Furthermore, the RAR1-SGT1 complex also interacts with two COP9 signalosome components. The interactions among RAR1, SGT1, SCF, and signalosome subunits indicate a link between disease resistance and ubiquitination.

Source: Science

DOI: 10.1126/science.1067554

Authors: Cristina Azevedo, Ari Sadanandom, Katsumi Kitagawa, Andreas Freialdenhoven, Ken Shirasu, Paul Schulze-Lefert

Institutions: John Innes Centre, Sainsbury Laboratory, St. Jude Children's Research Hospital, Max Planck Society

Language: English

Topic: Plant-Microbe Interactions and Immunity

Subfield: Plant Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Zero hunger

Open Access status: green

OpenAlex ID: W1985212818

FWCI: 73.74

Cites: 24

Cited by: 614

Related to: 9