Work

Aging, life span, and senescence

Year: 1998

Type: article

Abstract: In the budding yeast Saccharomyces cerevisiae, aging results from the asymmetry of cell division, which gives rise to a large mother cell and a small daughter cell arising from the bud. Much of the macromolecular composition of the daughter cell is newly synthesized, whereas the mother’s composition grows older with each cell division. By microscopic analysis, a single mother cell may be followed through multiple rounds of cell division. Thus, it was shown that mothers divide a relatively fixed number of times and undergo morphological changes of aging, including a slowing of the cell cycle, cell enlargement, and sterility (1).

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.95.19.11034

Authors: Leonard Guarente, Gary Ruvkun, Richard Amasino

Institutions: University of Wisconsin–Madison, Massachusetts General Hospital, Massachusetts Institute of Technology

Language: English

Topic: Genetics, Aging, and Longevity in Model Organisms

Subfield: Aging

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W1985334285

FWCI: 2.615

Cites: 22

Cited by: 45

Related to: 10