Work

An overview of the relationship between oxidative stress and chemical carcinogenesis

Year: 1991

Type: review

Abstract: Substantial experimental evidence exists which implicates both oxygen- and organic-free radical intermediates in the multiple stages of chemical carcinogenesis. This overview summarizes some of the biochemical and molecular interactions which could result from a state of oxidative stress following the generation of free radical intermediates from chemical carcinogens in target cells. Evidence for a relationship between carcinogenesis and inflammation as a mediator of oxidative stress is also discussed. Understanding the interactions of radical intermediates with target biomolecules should lead to the development of relevant biomarkers of these interactions as well as rational chemoprotective strategies with antioxidants or other radical detoxifiers for the prevention of neoplasia.

Source: Free Radical Biology and Medicine

DOI: 10.1016/0891-5849(91)90077-g

Authors: Michael A. Trush, Thomas W. Kensler

Institution: Johns Hopkins University

Language: English

Topic: Cancer and biochemical research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,240