Work

Determination of minimum bactericidal concentrations of oxacillin for Staphylococcus aureus: influence and significance of technical factors

Year: 1983

Type: article

Abstract: The minimum bactericidal concentration of oxacillin for Staphylococcus aureus was shown to be considerably influenced by technical and definitional factors, particularly by the survival of some organisms on the walls of test tubes and by the growth phase of the inoculum. Attention to technical detail greatly improved reproducibility, and log-phase cultures of all strains showed greater than 99.9% killing in 24 h, at or close to the minimum inhibitory concentration, including eight strains described as tolerant. Some strains showed the paradoxical phenomenon of having more survivors in higher concentrations above the minimum bactericidal concentration. An accepted reference minimum bactericidal concentration procedure is needed for establishing clinical correlates and for a review of endpoint criteria. Routine minimum bactericidal concentration tests on S. aureus should be interpreted with great caution.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.23.1.142

Authors: P C Taylor, F D Schoenknecht, J C Sherris, E C Linner

Institutions: University of Washington, Prince of Wales Hospital

Language: English

Topic: Antimicrobial Resistance in Staphylococcus

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W1985432986

FWCI: 17.89

Cites: 33

Cited by: 212

Related to: 10