Bone Mineral Status During and After Therapy of Childhood Cancer: An Increasing Population with Multiple Risk Factors for Impaired Bone Health
Year: 1999
Type: article
Abstract: W ITH SURVIVAL RATES for childhood cancers now ap- proaching 70%, (1,2) there is an urgent need to assess the nature, prevalence, and risk factors for long-term treatment sequelae.Survival rates for pediatric malignancies increased from 20% in 1965 to 66% in 1995.(3)(4)(5) As a result, it is anticipated that by the year 2000, 1 in every 900 individuals between the ages of 15 and 45 years will be a survivor of childhood cancer.(5,6) This growing population of long-term childhood cancer survivors represents a new group at risk for early onset osteoporosis.Adverse late effects resulting from impaired bone mineral density (BMD) (i.e., increased risk of early onset osteoporosis, fracture, and other bone defects) have been observed in cohorts of childhood cancer survivors of several primary tumor types.(7)(8)(9)(10)(11)(12)(13)(14) The frequency of diminished lumbar spine BMD has ranged from 8-23% of survivors who received chemotherapy prior to physeal closure.(7,8,15) The wide range of reported frequencies probably reflects the study of relatively small numbers of patients with diverse primary tumor types and treatments.The imprecise information about the prevalence, risk factors for, and treatment approaches for diminished BMD in pediatric patients further emphasizes the need for prospective study in these patients.
Language: English
Subfield: Orthopedics and Sports Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W1985453918