Year: 2012
Type: article
Abstract: Selective depletion of the alloreactive T cells causing graft-versus-host disease (GVHD) without loss of the graft-versus-leukemia (GVL) effect is the holy grail of hematopoietic cell transplantation (HCT). In this issue of Blood, He et al demonstrate that inhibition of histone methylation leads to selective apoptosis of the alloreactive effector cells. Moreover, they demonstrate that this inhibition of histone methylation remarkably stops ongoing GVHD.
Source: Blood
Author: Nelson Chao
Institution: Duke University
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W1985484293