Work

75: A novel antibody-based minimal intensity conditioning regimen for children with severe organ toxicity or DNA repair disorders

Year: 2007

Type: article

Abstract: Children with severe organ toxicities, DNA repair disorders and infants <1 year tolerate existing conditioning regimens, including reduced intensity conditioning, poorly. To reduce TRM in such patients, we used a minimal intensity conditioning regimen utilising 2 rat anti-CD45 monoclonal antibodies (Mabs) YTH24.5/YTH 54.12 for myelosuppression and Alemtuzumab (anti-CD52) for immunosuppression. As CD45 is expressed selectively on haemopoietic cells, the Mabs provide immunosuppression and transient myeloablation without the systemic toxicity associated with chemotherapy.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2006.12.078

Authors: K. Rao, G. Hale, M.K. Brenner, G.E. Davies, P. Veys, P.J. Amrolia

Institutions: Great Ormond Street Hospital, Baylor College of Medicine

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650