Work

Library of libraries: approach to synthetic combinatorial library design and screening of "pharmacophore" motifs.

Year: 1995

Type: article

Abstract: Construction of synthetic combinatorial libraries is described that allows for the generation of a library of motifs rather than a library of compounds. Peptide libraries based on this strategy were synthesized and screened with model targets streptavidin and anti-beta-endorphin antibody. The screens resulted in observation of expected motifs providing evidence of the effectiveness of the suggested approach.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.92.12.5426

Authors: N F Sepetov, V Krchnák, M Stanková, S Wade, K S Lam, M Lebl

Institution: University of Arizona

Language: English

Topic: Chemical Synthesis and Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute

Awards: DISCOVERY OF PEPTIDE ANTICANCER DRUGS, G6002107373