Work

Metabolism of progesterone to DOC, corticosterone and 18OHDOC in cultured human melanoma cells

Year: 1999

Type: article

Abstract: We are now showing that cultured human melanoma cells can synthesize steroids such as corticosterone from progesterone or deoxycorticosterone. Corticosterone production is strongly responsive to deoxycorticosterone substrate addition (12-fold increase), but unresponsive to the adrenal stimulating factors ACTH and angiotensin II. This is the first demonstration that skin cells (malignant melanocytes) have the capability to synthesize 11-deoxycorticosterone, corticosterone, and 18-hydroxydeoxycorticosterone.

Source: FEBS Letters

DOI: 10.1016/s0014-5793(99)00889-3

Authors: Andrzej Slominski, Celso E. Gomez-Sanchez, Mark F. Foecking, Jacobo Wortsman