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Robust shifts in S100a9 expression with aging: A novel mechanism for chronic inflammation

Year: 2013
Type: review
Abstract: The S100a8 and S100a9 genes encode a pro-inflammatory protein (calgranulin) that has been implicated in multiple diseases. However, involvement of S100a8/a9 in the basic mechanisms of intrinsic aging has not been established. In this study, we show that shifts in the abundance of S100a8 and S100a9 mRNA are a robust feature of aging in mammalian tissues, involving a range of cell types including the central nervous system. To identify transcription factors that control S100a9 expression, we performed a large-scale transcriptome analysis of 62 mouse and human cell types. We identified cell type-specific trends, as well as robust associations linking S100a9 coexpression to elevated frequency of ETS family motifs, and in particular, to motifs recognized by the transcription factor SPI/PU.1. Sparse occurrence of SATB1 motifs was also a strong predictor of S100a9 coexpression. These findings offer support for a novel mechanism by which a SPI1/PU.1-S100a9 axis sustains chronic inflammation during aging.
DOI: 10.1038/srep01215
Authors: William R. Swindell, Andrew Johnston, Xianying Xing, Andrew Little, Patrick Robichaud, John J. Voorhees, Gary Fisher, Johann E. Gudjonsson
Language: English
Open Access status: gold
Estimated APC paid: $2,690
Funders: Dermatology Foundation, American Skin Association, University of Michigan, A. Alfred Taubman Medical Research Institute, National Institutes of Health, National Institute on Aging, National Institute of Arthritis and Musculoskeletal and Skin Diseases
OpenAlex ID: W1985724051
FWCI: 0.595
Cites: 69
Cited by: 124
Related to: 10