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Mechanisms of Pathogenesis in Drug Hepatotoxicity Putting the Stress on Mitochondria

Year: 2010
Type: article
Abstract: Mitochondria play key roles in aerobic life and in cell death. Thus, interference of normal mitochondrial function impairs cellular energy and lipid metabolism and leads to the unleashing of mediators of cell death. The role of mitochondria in cell death due to drug hepatotoxicity has been receiving renewed attention and it is therefore timely to assess the current status of this area.
DOI: 10.1124/mi.10.2.7
Language: English
Subfield: Pharmacology
Open Access status: green
Funders: Pfizer, University of Southern California, Helsinn, National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Environmental Health Sciences
Awards: G1307570439, G1524048687, G1533535643, G1721600003, G1877827234, G2108293184, G2184571312, G251781573, Ethanol-Induced VDAC Closure in Hepatocytes, Cellular Mechanisms of Hepatotoxicity., G3894907260, G4288287806, G4359566550, G5235250476, G525203046, G5983454817, G6182624214, Mitochondrial Dysfunction and Drug Hepatotoxicity, G724704463, G7464057522, USC Research Center for Liver Disease, LIVER PRESERVATION FOR TRANSPLANTATION, G8013564434, Nuclear and cytoplasmic redox in oxidative stress, Transplantation of Reduced-Size Fatty Livers, G8940166694, G9000038454, G9000214817, G9000225851, G9000281188, G9000287525, G9000303802
OpenAlex ID: W1985776762
FWCI: 11.31
Cites: 127
Cited by: 82
Related to: 10