Work

Tyrosinase and related proteins in mammalian pigmentation

Year: 1996

Type: review

Abstract: Tyrosinase is the key enzyme in pigment synthesis, initiating a cascade of reactions which convert the amino acid tyrosine to the melanin biopolymer. Two other tyrosinase-related proteins (TRP) are known, TRP-1 (probably DHICAoxidase) and TRP-2 (DOPAchrome tautomerase). These proteins show about 40% homology, and recent results have indicated that the genes might be derived from a common ancestor. We will discuss recent findings on genomic organization, and on the proteins and their presumed function, which is important for eumelanin synthesis in mouse and man.

Source: FEBS Letters

DOI: 10.1016/0014-5793(96)00109-3

Authors: Véronique del Marmol, Friedrich Beermann

Institutions: Université Libre de Bruxelles, ISREC Foundation

Language: English

Topic: melanin and skin pigmentation

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W1985782120

FWCI: 0.55

Cites: 43

Cited by: 453

Related to: 10