Year: 2013
Type: article
Study design: Observational Study
Abstract: Despite global efforts to reduce measles incidence, outbreaks continue to occur in developing countries where HIV-1-infected adults represent a vulnerable population. Immunization campaigns have targeted children, although little is known about the levels of measles protection in adult populations in Kenya. The objective of this study was to determine seroprevalence and titers of measles IgG among HIV-1-infected and uninfected adults in Nairobi, Kenya. The presence of anti-measles IgG was measured in cryopreserved serum of 257 HIV-1-infected and 367 uninfected adults using a commercial ELISA (Enzygnost, Germany). The measles IgG concentration was calculated for those samples that were positive. Overall, 96% of adults were measles seropositive and the mean measles IgG concentration among those who were seropositive was 4134 mIU/ml, which is well above previously reported protective levels. There was no statistical difference in seroprevalence or antibody concentration between the HIV-infected and HIV-uninfected groups. While local vaccination efforts and circulating measles infection likely contribute to this high measles seroprevalence rate, these data are unique to an urban population and may not reflect a country-wide distribution. Our results suggest that reduced immunity among HIV-1-infected adults is not a major contributor to measles resurgence in Kenya.
Language: English
Topic: Virology and Viral Diseases
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,900
Funders: Vanderbilt University, University of Washington, National Institutes of Health, Center for AIDS Research, University of Washington, National Institute of Mental Health, National Institute of Allergy and Infectious Diseases, Fogarty International Center, National Center for Complementary and Alternative Medicine, Office of Women's Health
Awards: G1192006672, G1323885547, G2213881162, G2219438539, G346640147, HIV-1 and Protective Immunity against Common Childhood Pathogens, AIDS International Training and Research Program, G3985073149, Protective cellular immune responses in HIV-1 discordant couples, G6625095162, Fogarty International Clinical Research Scholars Support Center @ Vanderbilt-AAMC, G7791962275, G8021174655, G8221237752, G9000186388, University of Washington/Fred Hutch Center for AIDS Research
OpenAlex ID: W1985820866