Work

2-Cyano-pyrimidines: A New Chemotype for Inhibitors of the Cysteine Protease Cathepsin K

Year: 2007

Type: article

Abstract: Starting from the purine lead structure 1, a new series of cathepsin K inhibitors based on a pyrimidine scaffold have been explored. Investigations of P3 and P2 substituents based on molecular modeling suggestions resulted in potent cathepsin K inhibitors with an improved selectivity profile over other cathepsins.

Source: Journal of Medicinal Chemistry

DOI: 10.1021/jm0613525

Authors: Eva Altmann, Reiner Aichholz, Claudia Betschart, Thomas Buhl, Jonathan Green, Osamu Irie, Naoki Teno, René Lattmann, Marina Tintelnot-Blomley, Martin Missbach

Institution: Novartis Institutes for BioMedical Research

Language: English

Topic: Protease and Inhibitor Mechanisms

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W1985834096

FWCI: 1.93

Cites: 6

Cited by: 36

Related to: 10