Work

Stress and a Glycinergic Intervention Interact in the Modulation of MK-801–Elicited Mouse Popping Behavior

Year: 1999

Type: article

Abstract: The ability of D-cycloserine, a partial glycine agonist, to modulate mouse popping behavior elicited by MK-801, a noncompetitive NMDA receptor antagonist, was studied in unstressed and stressed mice. In unstressed animals, D-cycloserine (5.6 and 10 mg/kg) attenuated the ability of MK-801 (1.0 mg/kg) to elicit this behavior. However, the ability of D-cycloserine to attenuate MK-801-elicited mouse-popping behavior was not evident in stressed mice, 24 h after they were forced to swim for up to 10 min in cold water. Thus, the therapeutic value of glycinergic interventions may be limited by environmental factors, such as stress.

Source: Pharmacology Biochemistry and Behavior

DOI: 10.1016/s0091-3057(98)00167-1

Authors: Stephen I. Deutsch, Richard B. Rosse, Barbara L. Schwartz, Don G. Powell, John Mastropaolo

Institutions: United States Department of Veterans Affairs, Georgetown University, Veterans Health Administration, Washington DC VA Medical Center

Language: English

Topic: Neurotransmitter Receptor Influence on Behavior

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650