Work

CD40-TRAF6 and Autophagy-Dependant Anti-Microbial Activity in Macrophages

Year: 2007

Type: article

Abstract: A fundamental question in host-pathogen interaction is to determine if the immune system activates fusion with the lysosomes to eradicate pathogens. We recently reported that this task is accomplished by the interaction between CD40 expressed on macrophages and CD154 expressed on activated CD4+ T cells. CD40 stimulation of macrophages induces vacuole-lysosome fusion through autophagy and results in killing of the obligate intracellular pathogen Toxoplasma gondii. This response is independent of IFN-gamma, STAT1 and p47 GTPases. We now report that vacuole-lysosome fusion is dependent on synergy between TRAF6 signaling downstream of CD40 and TNF-alpha. These studies identified a new paradigm by which T cells eradicate an intracellular pathogen within macrophages.Addendum to:CD40 Induces Macrophage Anti-Microbial Activity by Triggering Autophagy-Dependent Fusion of Pathogen-Containing Vacuoles and LysosomesR.M. Andrade, M. Wessendarp. M.J. Gubbels, B. Striepen and C.S. SubausteJ Clin Invest 2006; 116:2366-77

Source: Autophagy

DOI: 10.4161/auto.3717

Authors: Carlos S. Subauste, Rosa M. Andrade, Matthew Wessendarp

Institutions: Case Western Reserve University, University of Cincinnati

Language: English

Topic: Toxoplasma gondii Research Studies

Subfield: Parasitology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Institute of Allergy and Infectious Diseases