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Acetaminophen and diphenhydramine as premedication for platelet transfusions: A prospective randomized double‐blind placebo‐controlled trial

Year: 2002

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: Non-hemolytic transfusion reactions (NHTR) occur in up to 30% of patients receiving platelet transfusions. Premedication with acetaminophen and diphenhydramine is a common strategy to prevent NHTR, but its efficacy has not been studied. In this prospective trial, transfusions in patients receiving pre-storage leukocyte-reduced single-donor apheresis platelets (SDP) were randomized to premedication with either acetaminophen 650 mg PO and diphenhydramine 25 mg IV, or placebo. Fifty-one patients received 98 transfusions. Thirteen patients had 15 NHTR: 15.4% (8/52) in the treatment arm and 15.2% (7/46) in the placebo arm. Premedication prior to transfusion of pre-storage leukocyte reduced SDP does not significantly lower the incidence of NHTR as compared to placebo.

Source: American Journal of Hematology

DOI: 10.1002/ajh.10119

Authors: Stephen E Wang, Primo N. Lara, Angie Lee‐Ow, Jeanne Reed, Lori R. Wang, Patti Palmer, Joseph M. Tuscano, Carol M. Richman, Laurel Beckett, Ted Wun

Institutions: VA Northern California Health Care System, University of California Davis Medical Center, University of California, Davis

Language: English

Topic: Blood transfusion and management

Subfield: Biochemistry

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W1986094971

FWCI: 1.268

Cites: 20

Cited by: 94

Related to: 10