Work

Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond

Year: 2006

Type: article

Abstract: Behavioral experiences can modulate neural networks through changes in synaptic morphology and number. In contrast, abnormal morphogenesis of dendritic spines is associated with cognitive impairment, as in Fragile X syndrome. Dendritic or synaptic protein synthesis could provide the specificity and speed necessary for spine morphogenesis. Here, we highlight locally translated proteins shown to affect synaptic morphology (e.g., Fragile X mental retardation protein).

Source: Journal of Neuroscience

DOI: 10.1523/jneurosci.1790-06.2006

Authors: Aaron W. Grossman, Georgina M. Aldridge, Ivan Jeanne Weiler, William T. Greenough

Institution: University of Illinois Urbana-Champaign

Language: English

Topic: Genetics and Neurodevelopmental Disorders

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid