Work

Immunotoxin Complementation of HAART to Deplete Persisting HIV-Infected Cell Reservoirs

Year: 2010

Type: article

Abstract: The development of combinations of drugs that potently suppress HIV replication, collectively given the acronym HAART (highly active antiretroviral therapy), has transformed the lives of people with HIV infection, particularly in highincome countries [1]. Though modern HAART regimens can drive HIV plasma viral loads below the detection limits of standard clinical assays ($50 copies HIV RNA/ml), long-term treatment fails to eradicate infectious virus as revealed by the persistence of HIV proviral DNA and infectious HIV in peripheral blood and lymphoid tissue, as well as by low level

Source: PLoS Pathogens

DOI: 10.1371/journal.ppat.1000803

Authors: Edward A. Berger, Ira Pastan

Institutions: National Institutes of Health, National Institute of Allergy and Infectious Diseases, National Cancer Institute

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,043