Work

Gene for the catalytic subunit of mouse DNA-dependent protein kinase maps to the scid locus.

Year: 1995

Type: article

Abstract: The gene encoding the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) has been proposed recently as a candidate gene for the mouse severe combined immune deficiency (scid) locus. We have used a partial cDNA clone for human DNA-PKcs to map the mouse homologue using a large interspecific backcross panel. We found that the mouse gene for DNA-PKcs does not recombine with scid, consistent with the hypothesis that scid is a mutation in the mouse gene for DNA-PKcs.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.92.23.10792

Authors: R D Miller, J Hogg, J H Ozaki, D Gell, S P Jackson, R Riblet

Institution: University of New Mexico

Language: English

Topic: DNA Repair Mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: Wellcome Trust, National Institutes of Health, National Institute of Allergy and Infectious Diseases

Awards: G1597933449, G2373476176, Genetic Analysis of the Immune System, ISOLATING THE SCID MOUSE DNA REPAIR GENE