Work

Familial Gestational Hyperthyroidism Caused by a Mutant Thyrotropin Receptor Hypersensitive to Human Chorionic Gonadotropin

Year: 1998

Type: article

Abstract: Some degree of stimulation of the thyroid gland by human chorionic gonadotropin is common during early pregnancy.1–3 When serum chorionic gonadotropin concentrations are abnormally high — for example, in women with molar pregnancies — overt hyperthyroidism may ensue. The pathophysiologic mechanism is believed to be promiscuous stimulation of the thyrotropin receptor by the excess chorionic gonadotropin.4,5 The explanation for this stimulation is the close structural relations between chorionic gonadotropin and thyrotropin and between their receptors.6 Hyperemesis gravidarum is characterized by excessive vomiting in early pregnancy, leading to the loss of 5 percent or more of body weight.4 It . . .

Source: New England Journal of Medicine

DOI: 10.1056/nejm199812173392505

Authors: Patrice Rodien, Catherine Brémont, Marie-Laure Raffin Sanson, Jasmine Parma, Jacqueline Van Sande, Sabine Costagliola, Jean-Pierre Luton, Gilbert Vassart, Laurence Duprez

Institutions: Université Libre de Bruxelles, Hôpital Cochin, Centre National de la Recherche Scientifique

Language: English

Topic: Thyroid Disorders and Treatments

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W1986364289

FWCI: 6.256

Cites: 26

Cited by: 345

Related to: 9